Active Education, Keeping It Personal and Making It Easy

Making it personal: translational bioinformatics

One of the most exciting research areas in Translational Bioinformatics 2 is related to the redefinition of fundamental notions of what constitutes a ‘disease.’ Nosology, the systematic classification of diseases, dates back to Carl Linnaeus, with the Genera Morborum Today, the improvement in our abilities to make molecular measurements related to health and disease has largely driven the revol...

Making it Easy to Deploy the UVM

The Universal Verification Methodology (UVM) is becoming the dominant approach for the verification of large digital designs. However, new users often express concern about the effort required to generate a complete and useful UVM testbench. But the practical experience collected in numerous OVM and UVM projects during the last few years shows a different view. The UVM is a very suitable method...

Making it personal; mentoring future family docs.

Biomarkers for rheumatoid arthritis: making it personal.

Effective treatment of rheumatoid arthritis (RA) has been hampered by the heterogeneity of the disease. Although early intervention can result in disease remission, it requires early diagnosis - and current diagnostic tests are not sufficiently accurate or sensitive in the early stages of RA. As a result, RA is typically diagnosed only once damage to the joints has already begun, a time at whic...

Keeping It Simple

The Post-Albers reaction scheme of the Na ϩ ,K ϩ-ATPase has been remarkably successful, for over a quarter-century , in explaining the biochemical behavior of the isolated enzyme, and is still the backbone of current bio-physical models for the various transport modes (elec-trogenic Na/K exchange; electroneutral and electrogenic Na/Na exchanges; K/K exchange, etc.) of the sodium pump. Because o...